Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
Abstract Due to a lack of published pharmacokinetic (PK) and/or pharmacodynamic (PD) data, decision-making surrounding appropriate dosing of cannabis used…
Research Article
Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia
Abstract Current treatments for stroke, which account for 6.5 million global deaths annually, remain insufficient for treatment of disability and…
Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function
Abstract Rationale: Pulmonary arterial hypertension (PAH) is a chronic disease associated with enhanced proliferation of pulmonary artery smooth muscle cells…
Impact of Alkali and Silane Treatment on Hemp/PLA Composites’ Performance: From Micro to Macro Scale
Abstract This study investigated the effect of hemp fiber pretreatments (water and sodium hydroxide) combined with silane treatment, first on…
Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
Abstract The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound…
Methamphetamine Blocks Adenosine A2A Receptor Activation via Sigma 1 and Cannabinoid CB1 Receptors
Abstract Methamphetamine is, worldwide, one of the most consumed drugs of abuse. One important side effect is neurodegeneration leading to…
Formulation of Cannabidiol in Colloidal Lipid Carriers
Abstract In this study, the general processability of cannabidiol (CBD) in colloidal lipid carriers was investigated. Due to its many…
Protective Effects of Cannabidiol on the Membrane Proteome of UVB-Irradiated Keratinocytes
Abstract Ultraviolet (UV) radiation contained in sunlight disturbs the redox state of skin cells, leading to changes in the structures…
Cannabidiol induces autophagy via ERK1/2 activation in neural cells
Abstract Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to the neuroprotection of the central…
Morbidity and mortality in schizophrenia with comorbid substance use disorders
Abstract Objective: Schizophrenia is highly comorbid with substance use disorders (SUD) but large epidemiological cohorts exploring the prevalence and prognostic…