Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation
Abstract Cannabinoid receptor 1 (CB1) is a promising drug target involved in many physiological processes. Using atomistic molecular dynamics (MD)…
Research Article
Effects of super-class cannabis terpenes beta-caryophyllene and alpha-pinene on zebrafish behavioural biomarkers
Abstract Terpenes possess a wide range of medicinal properties and are potential therapeutics for a variety of pathological conditions. This…
“Flower Power”: Controlled Inhalation of THC-Predominant Cannabis Flos Improves Health-Related Quality of Life and Symptoms of Chronic Pain and Anxiety in Eligible UK Patients
Abstract In November 2018, the UK’s Home Office established a legal route for eligible patients to be prescribed cannabis-based products…
Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze
Abstract Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has therapeutic potential for the treatment of anxiety. Most preclinical…
Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain
Abstract This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal…
Lip Bumper Therapy Does Not Influence the Sagittal Mandibular Incisor Position in a Retrospective CBCT Study
Abstract Lip bumper (LB) therapy is used as a treatment approach for mild to moderate crowding without extraction of teeth.…
Effects of Hemp Sanitary Pads on the Vaginal Microecology
Abstract Objective: To evaluate the effect of hemp cotton sanitary pads on the vaginal microecology. Methods: A randomized controlled field…
Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis
Abstract Rationale: Delta-9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another…
An Observational Cross-Sectional Survey Exploring the Indications for and Responses to Medical Marijuana Use in Certified Patients in Pennsylvania
Abstract Introduction/Objectives: Medical cannabis programs across the country vary and differ in their qualifying conditions for medical cannabis use. This…
Impacts of Different Light Spectra on CBD, CBDA and Terpene Concentrations in Relation to the Flower Positions of Different Cannabis Sativa L. Strains
Abstract Cannabis is one of the oldest cultivated plants, but plant breeding and cultivation are restricted by country-specific regulations. The…