The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer
Abstract The endocannabinoid system is widespread through the body and carries out a wide variety of functions. However, its involvement…
Research Article
Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding Affinity
Abstract The replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its main protease (Mpro), which…
Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic low back pain
Abstract Introduction: Chronic pain is a debilitating medical problem that is difficult to treat. Neuroinflammatory pathways have emerged as a…
Cannabis use disorder in relation to socioeconomic factors and psychiatric comorbidity: A cluster analysis of three million individuals born in 1970–2000
Abstract Background: Cannabis use disorder (CUD) is one of the main reasons for seeking substance use treatment. It is thus…
Lysophosphatidylinositol Induced Morphological Changes and Stress Fiber Formation through the GPR55-RhoA-ROCK Pathway
Abstract We previously reported that lysophosphatidylinositol (LPI) functions as an endogenous agonist of GPR55, a novel cannabinoid receptor. However, the…
Oral inhalation of cannabidiol delivered from a metered dose inhaler to alleviate cytokine production induced by SARS-CoV-2 and pollutants
Abstract Cannabidiol (CBD) was formulated as a metered dose inhaler (CBD-MDI) and evaluated in vitro for its efficacy as an…
Explainable machine learning analysis reveals sex and gender differences in the phenotypic and neurobiological markers of Cannabis Use Disorder
Abstract Cannabis Use Disorder (CUD) has been linked to a complex set of neuro-behavioral risk factors. While many studies have…
Similarities and differences in the nutritional composition of nuts and seeds in Serbia
Abstract Nuts and seeds are an indispensable part of the plant-based diet, which is becoming increasingly popular due to the…
Comparison of the in vitro Anti-Inflammatory Effect of Cannabidiol to Dexamethasone
Abstract Background: Cannabidiol (CBD) is a non-psychoactive phytocannabinoid constituent of Cannabis sativa with pain-relieving and anti-inflammatory properties. With the emphasis…
Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC Cannabis Extracts
Abstract Cannabis sativa is one of the oldest cultivated plants. Many of the medicinal properties of cannabis are known, although…