Cannabis use during the early COVID-19 pandemic: Use patterns, predictors, and subjective experiences
Abstract Background: Even in the early stages, global crises such as the COVID-19 pandemic lead to serious dislocations of social…
Research Article
Dexamethasone-Induced Fatty Acid Oxidation and Autophagy/Mitophagy Are Essential for T-ALL Glucocorticoid Resistance
Abstract Simple Summary: Reduced response to glucocorticoids (GCs, such as dexamethasone, Dex), first-line drugs employed during therapy induction, is considered…
Possibilities of Rock Processing with a High-Pressure Abrasive Waterjet with an Aspect Terms to Minimizing Energy Consumption
Abstract The paper concerns the application a high-pressure abrasive waterjet (AWJ) for cutting the most commonly used rock materials such…
Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells
Abstract Cannabinoid (CB) receptors (CB1 and CB2) are expressed on cancer cells and their expression influences carcinogenesis in various tumor…
Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling
Abstract The authors show that Δ9-trans-tetrahydrocannabinol, the main psychoactive compound in medicinal cannabis, could be considered as a therapeutic agent…
Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)
Abstract Background: To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell…
Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases
Abstract We report enzymes from the berberine bridge enzyme (BBE) superfamily that catalyze the oxidative cyclization of the monoterpene moiety…
Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice
Abstract The ventral tegmental area (VTA) mediates incentive salience and reward prediction error through dopamine (DA) neurons that are regulated…
Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling
Abstract Cannabidiol (CBD) is approved for treatment of seizures associated with two forms of epilepsy that become apparent in infancy…
A Longitudinal Observational Study of Medical Cannabis Use and Polypharmacy among Patients Presenting to Dispensaries in Pennsylvania
Abstract Background: Cannabis use is increasing among adults to treat a variety of health conditions. Given the potential for interactions…