Autophagy: An Emerging Target for Developing Effective Analgesics
Abstract Inadequate treatment of acute and chronic pain causes depression, anxiety, sleep disturbances, and increased mortality. Abuse and overdose of…
Research Article
Associations of alternative cannabis product use and poly-use with subsequent illicit drug use initiation during adolescence
Abstract Rationale: Specific cannabis products may differentially increase risk of initiating non-cannabis illicit drug use during adolescence. Objective: To determine…
Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint
Abstract Background: The metacarpophalangeal joint undergoes enormous loading during locomotion and can therefore often become inflamed, potentially resulting in osteoarthritis…
Cannabis Use Is Associated With Depression Severity and Suicidality in the National Comorbidity Survey−Adolescent Supplement
Abstract Objective: To investigate the association of cannabis use with major depression and suicidal behavior in adolescence. Method: Data are…
PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice
Abstract Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that regulate gene expression. Δ9-tetrahydrocannabinol (Δ9-THC) is a PPARg…
Sentiment analysis and emotion detection of post-COVID educational Tweets: Jordan case
Abstract Education evolved dramatically under Covid-19, and owing to the conditions, distant learning became mandatory. However, this has opened new…
Experience of Cannabis Use from Adolescence to Adulthood in France: An Interpretative Phenomenological Analysis
Abstract Levels of cannabis use are high during adolescence, but the proportion of cannabis users among adults is also progressing,…
Cannabidiol interacts with the FXR/Nrf2 pathway and changes the CB1/CB2 receptors ratio in gentamicin-induced kidney injury in rats
Abstract Objective(s): Gentamicin-induced nephrotoxicity was used as an experimental model of kidney disease. The present study was performed to assess…
Catalytic asymmetric synthesis of cannabinoids and menthol from neral
Abstract The selective conversion of natural or synthetic neral to (1R,6S)-trans-isopiperitenol would enable and expedite sustainable routes to menthol1,2 and…
Incidence of Intoxications in the Emergency Department of Galati Hospital with Examples of Cardiovascular Effects of MDMA Intoxication
Abstract MDMA (3,4-methylenedioxymethamphetamine; commonly referred to as “Molly” or “ecstasy”) is a synthetic compound, structurally and pharmacologically similar to both…