Rural inpatient hospitals and substance use—a 10-year retrospective analysis
Abstract Aim: To determine the burden and nature of substance use presentations within a defined rural region and provide an…
Research Article
Global Influence of Cannabis Legalization on Social Media Discourse: Mixed Methods Study
Abstract Background: Cannabis is the third most consumed drug worldwide, with its use linked to a high number of substance…
Pollenkitt From Narcissus tazetta: Evaluation of Its UV‐Protective Potential as a Plant‐Based Biomaterial Source
Abstract Pollenkitt, the lipid‐rich coating of pollen grains, is a promising natural ultraviolet (UV)‐protective source rich in phenolic and flavonoid…
ABCB1 polymorphisms are associated with clinical response to nabiximols in patients with multiple sclerosis-related spasticity
Keywords: Multiple sclerosis, Single nucleotide polymorphisms, Nabiximols, Spasticity, ABCB1 Authors: Alessandra Gemma, Marco Mauri, Paola Banfi, Maurizio Versino, Alen Zollo,…
A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis
Abstract Nuclear receptor farnesoid X receptor (FXR) acts as a key regulator of bile acid pool homeostasis and metabolism. Within…
Gender differences in opioid and stimulant poisoning in the central region of iran: a cross-sectional study
Abstract Despite the importance of sex differences in substance-related issues, regional studies have paid little attention to their impact on…
A Six-Gene Mitochondrial Signature Predicts Prognosis in Dedifferentiated Thyroid Cancer
Abstract Background: Dedifferentiated thyroid cancer (DDTC) is a highly malignant, infiltrative neoplasm. Studies confirm mitochondrial (MD) dysfunction links to DDTC’s…
SMPD2 affects the prognosis of cancer patients by mediating lipid metabolism and the immune microenvironment
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-03553-5. Article type: Research Article Keywords: SMPD2, Biomarker, Immune…
Pan-cancer analysis of the oncogenic role of ZNF703 in regulating tumor immunity
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-025-14636-5. Article type: Research Article Keywords: ZNF703, Tumor immunity,…
Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial
Abstract Chronic low back pain (CLBP) affects over half a billion people worldwide. Current pharmacologic treatments offer limited efficacy and…