Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
Abstract HCN4 channels play an important role in cardiac action potential initiation in the sinoatrial node. In this study, Page…
Research Article
Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR-α pathways
Abstract Liver fibrosis has become a serious public health problem that can develop into liver cirrhosis and hepatocellular carcinoma and…
Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
Abstract The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment…
Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections
Abstract Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median effective and toxic concentrations (EC50, CC50) of…
Genetic insights into agronomic and morphological traits of drug-type cannabis revealed by genome-wide association studies
Abstract Cannabis sativa L., previously concealed by prohibition, is now a versatile and promising plant, thanks to recent legalization, opening…
Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
Abstract Post-traumatic stress disorder (PTSD) is the most common psychiatric disorder after a catastrophic event; however, the efficacious treatment options…
Elemental Composition of Commercially Available Cannabis Rolling Papers
Abstract With the recent legalization of cannabis in multiple jurisdictions and widespread use as a medical treatment, there has been…
Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABAA receptors
Abstract The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients…
CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity
Abstract While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for another…
“Everything is kind of the same except my mind is with me”: exploring cannabis substitution in a sample of adults in early recovery from an opioid or stimulant addiction
Abstract Background: Recovery from addiction is frequently equated with abstinence. However, some individuals who resolve an addiction continue to use…