Identification of hub genes and potential molecular mechanisms related to radiotherapy in thyroid cancer
Abstract Radiotherapy is a common approach during the treatment of thyroid cancer (THCA). It is urgent to identify the radiotherapy-related…
Research Article
Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
Abstract The discovery by cryo-electron microscopy (cryo-EM) that the neu-ropathological hallmarks of different tauopathies, including Alzheimer’s disease, corticobasal degeneration (CBD),…
In Web We Trust: The Promised Cannabidiol Effects on Obesity as a Matter of Language and Marketing on Webpages
Abstract Background: Today more and more people search the web for health-related information, risking to come across misinformation and biased…
Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes
Abstract The two most extensively studied cannabinoids, cannabidiol (CBD) and delta‐9‐tetrahydrocannabinol (THC), are used for myriad conditions. THC is predominantly…
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway
Abstract Objective: The aim of this study is to investigate the protective effect of Cannabidiol (CBD) on DSS-induced colitis in…
Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-84916-w. Article type: Research Article Keywords: GLS, Pan-cancer analysis,…
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-83714-8. Article type: Research Article Keywords: NET1, Pan-cancer, Prognosis,…
Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets
Abstract Molecular subtypes, such as defined by The Cancer Genome Atlas (TCGA), delineate a cancer’s underlying biology, bringing hope to…
Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer
Abstract Background: The Apoptosis-Stimulating Protein of P53 (ASPP) family contributes to apoptosis regulation and tumor suppression, with ASPP1 influencing processes…
Substance use and disordered eating risk among college students with obsessive-compulsive conditions
Abstract Purpose: College students are at higher risk for problematic substance use and disordered eating. Few studies have examined the…