Three-dimensional genome architecture in intrahepatic cholangiocarcinoma
Abstract Purpose: Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with a 5-year survival rate of less than 20%.…
Research Article
FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-86185-7. Article type: Research Article Keywords: FLT3, AML, Hepatocellular…
Molecular Subtyping and Genomic Profiling Expand Precision Medicine in KRAS Wild‐Type Pancreatic Cancer
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis and limited treatment options. While the majority…
Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice
Abstract The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric…
Everyday Ethnic Discrimination and Early Substance Use Based on Hair Samples in High-Risk Racial/Ethnic Minority Early Adolescents
Abstract Objectives: Although racially and ethnically minoritized youth are more likely to experience adverse effects of substance use, and substance…
Comparative, Cost and Multi-Criteria Analyses of Traditional Binders in the Composition of Hemp-Based Finishing Products
Abstract The objective of this paper is to analyze the characteristics of twelve compositions based on hemp shiv and four…
Impact of a Novel Two-Phase Natural Deep Eutectic Solvent-Assisted Extraction on the Structural, Functional, and Flavor Properties of Hemp Protein Isolates
Abstract Defatting dehulled hemp seeds is a crucial step prior to protein extraction. However, conventional methods rely on flammable solvents,…
∆9-Tetrahydrocannabinol Increases Growth Factor Release by Cultured Adipose Stem Cells and Adipose Tissue in vivo
Abstract Because of its biocompatibility and its soft and dynamic nature, the grafting of adipose tissue is regarded an ideal…
The Impact of a Healthy Lifestyle on Lower Urinary Tract Symptoms and Erectile Function: A Prospective Study
Abstract Background and Objectives: The impact of lifestyle on lower urinary tract symptoms has been deeply evaluated in recent years;…
Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity
Abstract Prenatal cannabis use is associated with neurodevelopmental deficits, likely due to exposure to the psychoactive cannabinoid, (-)-Δ9-tetrahydrocannabinol, and its…