CANDI: a web server for predicting molecular targets and pathways of cannabis-based therapeutics
Abstract Background: Cannabis sativa L. with a rich history of traditional medicinal use, has garnered significant attention in contemporary research…
Research Article
Pro-Apoptotic Effects of Anandamide in Human Gastric Cancer Cells Are Mediated by AKT and ERK Signaling Pathways
Abstract Gastric cancer is one of the most common forms of cancer worldwide. A growing number of studies have addressed…
Bioactive Compound Characterization and Phytopharmacological Potentials of Tulbaghia violacea Fruits and Seeds
Abstract Tulbaghia violacea is an established medicinal plant that is indigenous to southern Africa. All its plant parts have been…
Diagnostics and immunological function of CENPN in human tumors: from pan-cancer analysis to validation in breast cancer
Abstract Background: Centromere protein N (CENPN), a member of the centromere protein family, contributes to ribonucleic assembly, mitosis progression, and…
Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer
Abstract Purpose: Pancreatic adenocarcinoma (PAAD) is a highly aggressive cancer with a poor prognosis, reliable markers are urgently needed for…
Scupa: single-cell unified polarization assessment of immune cells using the single-cell foundation model
Abstract Motivation: Immune cells undergo cytokine-driven polarization in response to diverse stimuli, altering their transcriptional profiles and functional states. This…
Pan-Cancer Characterization Identifies SLC19A1 as an Unfavorable Prognostic Marker and Associates It with Tumor Infiltration Features
Abstract Background: Recent studies have identified solute carrier family 19 member 1 (SLC19A1) as a second messenger transporter that regulates…
Special needs of refugees with substance use disorders from conflict-affected countries: a comparison with German-born individuals
Abstract Background: Refugees seem to be at enhanced risk for substance use disorders. At the same time, they have less…
Low doses of cannabis extract ameliorate non-motor symptoms of Parkinson’s disease patients: a case series
Keywords: cannabis, THC, CBD, Parkinson’s disease, cognition, insomnia, sleepiness, case series Authors: Ana Carolina Ruver-Martins, Ingrid Andrea Rodriguez Martinez, Vinicius…
A comprehensive analysis of the prognostic value, expression characteristics and immune correlation of MKI67 in cancers
Abstract Background: nuclear-associated antigen Ki67 (Ki67) emerges as a clinically practical biomarker for proliferation assessment among many cancer types. However,…