Comprehensive Pan-cancer Analysis Revealed CASP10 As a Promising Biomarker For Diverse Tumor Types
Abstract We aimed to explore the comprehensive cancer landscape of Caspase-10 (CASP10). CASP10, a member of the caspase family, is…
Research Article
A Network-Based Approach Exploiting Transcriptomics and Interactomics Data for Predicting Drug Repurposing Solutions Across Human Cancers
Abstract Drug repurposing can be an effective way to identify potential therapies for various diseases. Biological networks can be useful…
ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling
Abstract Triple‐negative breast cancer (TNBC) is highly metastatic and presents clinical challenges given the lack of targeted therapies. Here, we…
Kazakhstani Drivers and Substance Abuse During COVID-19: A Study of Patterns and Disaster Readiness
Abstract Background/Objectives: The COVID-19 pandemic has significantly affected public health and social behavior, contributing to increased psychoactive substance (PAS) use…
Substance use among young people in the West Arsi Zone, Ethiopia: A cross-sectional study
Abstract Introduction: Substance use is a pressing public health concern in young Ethiopians, impacting their physical, psychosocial, and emotional well-being…
Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy
Abstract This study examines the link between vascular endothelial growth factor inhibitors (VEGFi) and VEGF receptor inhibitors (VEGFRi) used in…
Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors
Abstract Introduction: Microsomal triglyceride transfer protein (MTTP) is an essential lipid transfer protein for the synthesis and secretion of very…
Prognostic Role of SETDB2 in Clear Cell Renal Cell Carcinoma: Linking Immune Infiltration, Cuproptosis, and Tumor Suppression
Abstract Background: Clear cell renal cell carcinoma (ccRCC) is a relatively frequently diagnosed form of urological cancer that is highly…
Thermal Comfort Properties of Biodegradable Hemp and Polylactide Fiber Knitted Fabrics
Abstract According to the global strategy of Green course, the production of sustainable textiles using different biodegradable fibres has immense…
Design and Computational Study of Sulfonamide-Modified Cannabinoids as Selective COX-2 Inhibitors Using Semiempirical Quantum Mechanical Methods: Drug-like Properties and Binding Affinity Insights
Abstract Cyclooxygenase (COX) is one of the concerned targets in the development of anti-inflammatory therapies. Using semiempirical quantum mechanical (SQM)…