Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists
Abstract Transient receptor potential vanilloid (TRPV) 4 is involved in signaling pathways specifically mediating pain and inflammation, making it a…
Research Article
Mitigating the Risk of QTc Prolongation When Using Haloperidol for Acute Treatment of Cannabinoid Hyperemesis Syndrome in Adolescents and Young Adults
Abstract Background/Objectives: Cannabinoid Hyperemesis Syndrome (CHS), associated with long-term cannabinoid use, has been increasingly observed in emergency room visits as…
The Impact of Polymerized Whey Protein on the Microstructure, Probiotic Survivability, and Sensory Properties of Hemp Extract-Infused Goat Milk Yogurt
Abstract Goat milk yogurt infused with hemp extract (HE) is a novel dairy product; however, the unpleasant flavors from hemp…
Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics
Abstract Cannabis use disorder affects up to 42% of individuals with schizophrenia, correlating with earlier onset, increased positive symptoms, and…
Efficacy of Natural β-Carotene Chewable Tablets Derived from Banana (Musa AA) Pulp in Reducing UV-Induced Skin Erythema
Abstract Background/Objectives: UV radiation is a primary cause of skin damage and photoaging. β-carotene, a potent antioxidant, aids in mitigating…
Microstructural Characteristics of Cellulosic Fiber-Reinforced Cement Composite
Abstract The microstructural evolution and hydration behaviors of cement composites incorporating three natural fibers (abaca, hemp, and jute) were investigated…
Design of Small Non-Peptidic Ligands That Alter Heteromerization between Cannabinoid CB1 and Serotonin 5HT2A Receptors
Abstract Activation of cannabinoid CB1 receptors (CB1R) by agonists induces analgesia but also induces cognitive impairment through the heteromer formed…
Detection of Body Packs in Abdominal CT scans Through Artificial Intelligence; Developing a Machine Learning-based Model
Abstract Introduction: Identifying the people who try to hide illegal substances in the body for smuggling is of considerable importance…
Exploring the Therapeutic Potential of Cannabidiol in U87MG Cells: Effects on Autophagy and NRF2 Pathway
Abstract Cannabinoids include both endogenous endocannabinoids and exogenous phytocannabinoids, such as cannabidiol (CBD), and have potential as therapeutic agents in…
Association between cannabis use and clinical outcomes in patients with solid malignancies receiving immune checkpoint inhibitors
Abstract Background: Cannabis (CAN) use has risen significantly over the last few decades. CAN has potent immunosuppressive properties, which could…