Complement dysregulation in human tauopathies
Abstract Dysregulation of the complement system plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD).…
Research Article
Immunotyping of thyroid cancer for clinical outcomes and implications
Abstract Background: Tumor immune microenvironment (TIME) plays a crucial role in cancer development. However, the prognostic significance of immune-related genes…
Cannabidiol Extracted from Cannabis sativa L. Plant Shows Neuroprotective Impacts Against 6-HODA-Induced Neurotoxicity via Nrf2 Signal Transduction Pathway
Abstract Background: As a prevalent neurodegenerative illness, Parkinson’s disease (PD) is associated with serious disability and reduced quality of patients’…
Rotenoids from the Roots of Vicia faba L. (Fabaceae): Structural Characterization, Cytotoxic Effects, and Molecular Docking
Abstract The chemical study of the ethanolic extract from the roots of Vicia faba led to the isolation of two…
Efficacy of the GLP-1 receptor agonist, semaglutide, in abstinence from illicit and nonprescribed opioids in an outpatient population with treatment-refractory OUD: A randomized, double-blind, placebo-controlled clinical trial protocol
Abstract Background: Standard medications for opioid used disorder (MOUD) provide effective treatment pathways for recovery compared with no treatment or…
Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor
Abstract Nutraceuticals provide health benefits and particularly profit from a sensitive, high-purity production process. Microparticle laser fragmentation in liquids is…
Transcriptomic analysis of wild Cannabis sativa: insights into tissue- and stage-specific expression and secondary metabolic regulation
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12864-025-11697-5. Article type: Research Article Keywords: Transcriptomics, Secondary metabolism,…
Discovery of major QTL and a massive haplotype associated with cannabinoid biosynthesis in drug‐type Cannabis
Abstract Cannabis (Cannabis sativa L.), once sidelined by decades of prohibition, has now gained recognition as a multifaceted and promising…
The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database
Abstract Objective: To analyze the expression and significance of resistin (RETN) in pan-cancer and determine the prospect of RETN as…
Opioid Use Following Primary Unilateral Total Knee Arthroplasty Varies With Age
Abstract Background: Reducing unused prescribed opioids following arthroplasty procedures remains a challenge. The relationship between opioid consumption and age has…