Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types
Abstract The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex…
Brief Report
Gastric Parietal Cell and Intestinal Goblet Cell Secretion: a Novel Cell-Mediated In Vivo Metal Nanoparticle Metabolic Pathway Enhanced with Diarrhea Via Chinese Herbs
Abstract Electronic supplementary material: The online version of this article (10.1186/s11671-019-2908-z) contains supplementary material, which is available to authorized users.…
Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
Abstract XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the recruitment of Polβ, LigIIIα,…
Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression
Abstract The endocannabinoid system (ECS) has been recently recognized as a prominent promoter of the emotional homeostasis, mediating the effects…
Tualang honey ameliorates viral load, CD4 counts and improves quality of life in asymptomatic human immunodeficiency virus infected patients
Abstract This is the first study to report on the effects of honey in asymptomatic HIV positive subjects in ameliorating…
24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson’s Disease and Corticobasal Syndrome
Abstract 24S-hydroxycholesterol (24OHC) and Tau are produced in neuronal cells and neurodegeneration leads to increased flux of both of them…
Cannabis Legalization in Canada: Reflections on Public Health and the Governance of Legal Psychoactive Substances
Abstract The Canadian government is “taking a public health approach to legalizing, strictly regulating and restricting access to cannabis.” There…
Transition to practice: creation of a transitional rotation for radiation oncology
Abstract Background: Implementation of Competence by Design (CBD) will require residency training programs to develop formalized “Transition to Practice” (TTP)…
Second-Hand Exposure of Staff Administering Vaporised Cannabinoid Products to Patients in a Hospital Setting
Abstract Background: In many health settings, administration of medicinal cannabis poses significant implementation barriers including drug storage and safety for…
Synthesis and Cytotoxic Activity of Novel Tetrahydrocurcumin Derivatives Bearing Pyrazole Moiety
Abstract Abstract: Tetrahydrocurcumin (THC) is a major metabolite of curcumin and plays an important role in curcumin-induced biological effects. THC…