Forty sites of TRP channel regulation
Abstract Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert…
X-ray crystallography
The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba
Abstract Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity of natural products to the benefit of host…
Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
Abstract The cannabinoid receptors CB1 and CB2 mediate a variety of physiological processes and continue to be explored as desirable…
Biophysical Studies and In Vitro Effects of Tumor Cell Lines of Cannabidiol and Its Cyclodextrin Inclusion Complexes
Abstract Phytocannabinoids possess anticancer properties, as established in vitro and in vivo. However, they are characterized by high lipophilicity. To…
Defining molecular glues with a dual-nanobody cannabidiol sensor
Abstract “Molecular glue” (MG) is a term coined to describe the mechanism of action of the plant hormone auxin and…
FABP1 controls hepatic transport and biotransformation of Δ9-THC
Abstract The increasing use of medical marijuana highlights the importance of developing a better understanding of cannabinoid metabolism. Phytocannabinoids, including…
Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family
Abstract Flavin-dependent enzymes catalyze many oxidations, including formation of ring structures in natural products. The gene cluster for biosynthesis of…