In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine
Abstract Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development…
voltage-gated sodium channels
Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
Abstract Chronic pain is a major health problem worldwide; however, treatment options remain limited and often involve adverse side-effects or…
Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels
Abstract Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in…
A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function
Abstract Background: Purified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal…
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
Abstract Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels’ function can lead to many pathophysiological…
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967
Abstract Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by epilepsy mutations…
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Abstract Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and…