Importance of PERK pathway modulation on colorectal cancer management: a systematic review
Abstract Background: The protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the Unfolded Protein Response (UPR) plays a complex…
unfolded protein response
Proteome-Wide Profiling Using Sample Multiplexing of a Human Cell Line Treated with Cannabidiol (CBD) and Tetrahydrocannabinol (THC)
Abstract Cannabis has been used historically for both medicinal and recreational purposes, with the most notable cannabinoids being cannabidiol (CBD)…
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Abstract Graphical Abstract: Article type: Review Article Keywords: Alzheimer’s disease, Sleep, Proteostasis, Autophagy, Unfolded protein response, Tau, β-amyloid Authors: Christopher…
Δ8-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis
Abstract Alzheimer’s disease (AD) represents the most common form of dementia, characterized by amyloid β (Aβ) plaques and neurofibrillary tangles…
Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis
Abstract The major cellular event in the development and progression of liver fibrosis is the activation of hepatic stellate cells…