Importance of PERK pathway modulation on colorectal cancer management: a systematic review
Abstract Background: The protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the Unfolded Protein Response (UPR) plays a complex…
unfolded protein response
A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide
Abstract Investigating amyloid–β (Aβ) peptides in solution is essential during the initial stages of developing lead compounds that can influence…
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer
Abstract Background: Stomach cancer is a leading cause of cancer-related deaths globally due to its high grade and poor response…
Proteome-Wide Profiling Using Sample Multiplexing of a Human Cell Line Treated with Cannabidiol (CBD) and Tetrahydrocannabinol (THC)
Abstract Cannabis has been used historically for both medicinal and recreational purposes, with the most notable cannabinoids being cannabidiol (CBD)…
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Abstract Graphical Abstract: Article type: Review Article Keywords: Alzheimer’s disease, Sleep, Proteostasis, Autophagy, Unfolded protein response, Tau, β-amyloid Authors: Christopher…
Δ8-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis
Abstract Alzheimer’s disease (AD) represents the most common form of dementia, characterized by amyloid β (Aβ) plaques and neurofibrillary tangles…
The unfolded protein response links tumor aneuploidy to local immune dysregulation
Abstract Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here, we tested the hypothesis that…
EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling
Abstract Background: Somatic mutations are involved in hepatocellular carcinoma (HCC) progression, but the genetic mechanism associated to hepatocarcinogenesis remains poorly…
Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis
Abstract The major cellular event in the development and progression of liver fibrosis is the activation of hepatic stellate cells…