Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-73455-z. Article type: Research Article Keywords: FBXO2, Papillary thyroid…
Abstract Background: RING Finger Protein 115 (RNF115), a notable E3 ligase, is known to modulate tumorigenesis and metastasis. In our…
Abstract Background: Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether…
Abstract Background: The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely…
Abstract The F-box protein 22 (FBXO22), an F-box E3 ligase, has been identified to be critically involved in carcinogenesis. However,…
Abstract Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins…
Abstract In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing…
Abstract Family with sequence similarity 46 member C (FAM46C) is a non-canonical poly(A) polymerase that is associated with tumorigenesis. However,…
Abstract Background: Rbx1/ROC1 is an E3 ligase adaptor protein that functions with the E2 enzyme CDC34. Results: NMR and biochemical…