Homeobox and Polycomb target gene methylation in human solid tumors
Abstract DNA methylation is an epigenetic mark that plays an important role in defining cancer phenotypes, with global hypomethylation and…
Tumour biomarkers
Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis
Abstract MAPK pathway-driven tumorigenesis, often induced by BRAFV600E, relies on epithelial dedifferentiation. However, how lineage differentiation events are reprogrammed remains…
Pan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers
Abstract RAB3B is essential for the transportation and secretion within cells. Its increased expression is linked to the development and…
CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer
Abstract Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential…
Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides
Abstract Programmed cell death ligand 1 (PDL1), as an important biomarker, is quantified by immunohistochemistry (IHC) with few established histopathological…
CD74 as a prognostic and M1 macrophage infiltration marker in a comprehensive pan-cancer analysis
Abstract CD74 is a type-II transmembrane glycoprotein that has been linked to tumorigenesis. However, this association was based only on…
Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
Abstract Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating…
A systematic pan-cancer study on deep learning-based prediction of multi-omic biomarkers from routine pathology images
Abstract Background: The objective of this comprehensive pan-cancer study is to evaluate the potential of deep learning (DL) for molecular…
A pan-cancer analysis uncovering the function of CRHBP in tumor immunity, prognosis and drug response: especially its function in LIHC
Abstract Corticotropin-releasing hormone-binding protein (CRHBP) is involved in many physiological processes. However, it is still unclear what role CRHBP has…
PRKCSH serves as a potential immunological and prognostic biomarker in pan-cancer
Abstract Protein kinase C substrate 80K-H (PRKCSH) plays a crucial role in the protein N-terminal glycosylation process, with emerging evidence…