Troponin T1 in tumorigenesis and immune modulation: Insights into multiple cancers and kidney renal clear cell carcinoma
Abstract Troponin T1 (TNNT1) plays a crucial role in muscle contraction but its role in cancer, particularly in kidney renal…
tumorigenesis
HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)
Abstract Helicase POLQ-like (HELQ or Hel308), is a highly conserved, 3′-5′ superfamily II DNA helicase that contributes to diverse DNA…
TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer
Abstract Objective: To investigate the role and clinical significance of threonine tyrosine kinase (TTK) in papillary thyroid cancer (PTC). Methods:…
Identification and validation of PCSK9 as a prognostic and immune-related influencing factor in tumorigenesis: a pan-cancer analysis
Abstract Introduction: Proprotein convertase subtilisin/kexin-9 (PCSK9) has been primarily studied in the cardiovascular field however, its role in cancer pathophysiology…
The roles of FLOT1 in human diseases (Review)
Abstract FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including lipid raft protein-dependent or clathrin-independent…
Human leukocyte antigen and tumor immunotherapy (Review)
Abstract Malignant tumors seriously endanger human health and life, and restrict economic development. Human leukocyte antigen (HLA) is the expression…
Multi-functional gene ZNF281 identified as a molecular biomarker in soft tissue regeneration and pan-cancer progression
Abstract Regeneration and tumorigenesis are indicated as related processes, while regeneration leads to life and the outcome of tumorigenesis is…
SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic Implications
Abstract Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is a cullin 3-based E3 ubiquitin ligase adaptor protein…
A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and Immunity
Abstract Introduction: Epigenetic-targeted therapy has been increasingly applied in the treatment of cancers. Lysine (K)-specific demethylase 6B (KDM6B) is an…
Prognostic Implication and Oncogenic Role of PNPO in Pan-Cancer
Abstract Objective: Pyridoxine 5′-phosphate oxidase (PNPO) is a key enzyme in the metabolism of vitamin B6 and affects the tumorigenesis…