The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
Abstract DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In…
tumor progression
Transient Receptor Potential Cation Channels in Cancer Therapy
Abstract In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid),…
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
Abstract Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs),…