Association analysis of FXYD5 with prognosis and immunological characteristics across pan-cancer
Abstract Background: The FXYD domain-containing ion transport regulator 5 (FXYD5) gene is a cancer promoter. However, evidence for an association…
tumor immune microenvironment
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer
Abstract Background: Stomach cancer is a leading cause of cancer-related deaths globally due to its high grade and poor response…
Pan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation
Abstract Background: Interleukin-4 inducible gene 1 (IL4I1) regulates tumor progression in numerous tumor types. However, its correlation with immune infiltration…
Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration
Abstract Background: NADPH oxidase 4 (NOX4) has been proven to be associated with the prognosis of tumors in multiple cancers…
Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy
Abstract Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic…
Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches
Abstract Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and…
Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier
Abstract The first PTC patient classifier defined by tumor macrophage differentiation. Integrated sequencing data identifies key gene sets. Macrophage states…
Elucidating the role of Pyroptosis in papillary thyroid cancer: prognostic, immunological, and therapeutic perspectives
Abstract Background: Pyroptosis, an inflammatory form of programmed cell death, has been implicated in the pathogenesis and progression of several…
m6A modification patterns are associated with copy number burden and tumor immune landscape in thyroid cancer
Abstract Background: The association involving N6-methyladenosine (m6A) modification, molecular subtype and specific immune cell group in tumor microenvironment has been…
Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3
Abstract TRIB3, a pseudokinase, was previously studied within only some specific cancer types, leaving its comprehensive functions in pan-cancer contexts…