Immunotyping of thyroid cancer for clinical outcomes and implications
Abstract Background: Tumor immune microenvironment (TIME) plays a crucial role in cancer development. However, the prognostic significance of immune-related genes…
tumor immune microenvironment
Deciphering the multifaceted role of EXO1 in female-related cancers: implications for prognosis and therapeutic responsiveness
Abstract Background: Aberrant function or overactivation of exonuclease 1 (EXO1) may be associated with cancer tumor development, drug resistance, and…
Transcriptome sequencing revealed that lymph node metastasis of papillary thyroid microcarcinoma is associated with high THBS4 expression and PDGFRA+ cancer-associated fibroblasts
Abstract Background: Cervical lymph node metastasis is a major factor influencing recurrence after surgery for papillary thyroid cancer. Molecular markers…
Pan-cancer analysis of ITGB3 as a potential prognostic and immunological biomarker
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-02300-0. Article type: Research Article Keywords: ITGB3, Prognosis, Tumor…
The role of TRAF2 in pan-cancer revealed by integrating informatics and experimental validation
Abstract Background: Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an E3 ubiquitin ligase and scaffolding protein that contribute…
Exploring the genetic profiles linked to senescence in thyroid tumors: insights on predicting disease progression and immune responses
Abstract Introduction: Thyroid cancer (THCA) is the most common endocrine tumor. Research on Cell Senescence Associated Genes (CSAGs), which impact…
Evaluation of Pan-Cancer Immune Heterogeneity Based on DNA Methylation
Abstract Background/Objectives: The heterogeneity of the tumor immune microenvironment is a key determinant of tumor oncogenesis. This study aims to…
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway
Abstract Background: UCHL5 was initially recognized as a multifunctional molecule. While recent research has highlighted its involvement in tumor malignant…
A pan-cancer analysis of the oncogenic role of N-acetyltransferase 8 like in human cancer
Abstract Background: N-Acetyltransferase 8 Like (NAT8L) inhibits natural killer (NK)/T-cell cytotoxicity by impairing the formation of the immunological synapse via…
Migrasome regulator TSPAN4 shapes the suppressive tumor immune microenvironment in pan-cancer
Abstract Background: Migrasomes are newly identified organelles on the retracting fibers of migrating cells, involved in releasing signaling molecules, expelling…