Abstract Background: Emerging evidence highlights the overexpression of Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) in multiple malignancies. However, its pan-cancer prognostic significance,…
Abstract Background: Glyoxalase 1 (GLO1), an enzyme responsible for breaking down methylglyoxal (MG), is increasingly recognized as a tumor-promoting factor…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40001-025-03404-7. Article type: Research Article Keywords: LMBR1L expression, Tumor…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40246-025-00850-6. Article type: Research Article Keywords: USP35, Energy metabolism…
Abstract F-box and leucine-rich repeat protein 22 (FBXL22) has been implicated in breast and prostate cancer types; however, comprehensive pan-cancer…
Abstract Background/Objectives: FAM72B (Family with sequence similarity 72 member B) is a gene whose function is not yet fully elucidated…
Abstract Senescent immune cells secrete varied inflammatory factors that weaken the systemic anti-tumor ability and promote the proliferation and metastasis…
Abstract Background: Immunoglobulin superfamily member 8 (IGSF8) is a membrane protein implicated in crucial biological processes like cell interactions and…
Abstract This study investigates the role of T cells in thyroid cancer, a major factor in determining the prognosis of…
Abstract Objective: ME1 catalyzes the conversion of malic acid into acetic acid, thereby linking glucose metabolism to the citric acid…