Cannabidiol in Neurology: Current Insights and Translational Perspectives
Abstract Cannabidiol (CBD) is one of the most studied compounds of Cannabis sativa and has attracted significant interest due to…
traumatic brain injury
Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies
Abstract Highlights: What are the main findings? What are the implications of the main findings? Abstract: Headache disorders, including migraine,…
Cannabidiol alleviates the inflammatory response in rats with traumatic brain injury through the PGE 2-EP2-cAMP-PKA signaling pathway
Abstract Traumatic brain injury (TBI) is a recognized global public health problem. However, there are still limitations in the available…
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer’s-prone mice after mTBI
Abstract Background: Despite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular…
Traumatic Brain Injury Outcomes After Recreational Cannabis Use
Abstract Purpose: Basic science data indicate potential neuroprotective effects of cannabinoids in traumatic brain injury (TBI). We aimed to evaluate…
Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders
Abstract The oxytosis/ferroptosis regulated cell death pathway is an emerging field of research owing to its pathophysiological relevance to a…
Cannabis use disorder contributes to cognitive dysfunction in Veterans with traumatic brain injury
Abstract Background: While emerging evidence supports a link between traumatic brain injury (TBI) and progressive cognitive dysfunction in Veterans, there…
The economic impact of cannabis use disorder and dementia diagnosis in veterans diagnosed with traumatic brain injury
Abstract Background: Studies have demonstrated that individuals diagnosed with traumatic brain injury (TBI) frequently use medical and recreational cannabis to…
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Abstract Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20%…
Cannabidiol’s neuroprotective properties and potential treatment of traumatic brain injuries
Abstract Cannabidiol (CBD) has numerous pharmacological targets that initiate anti-inflammatory, antioxidative, and antiepileptic properties. These neuroprotective benefits have generated interest…