Disrupting GPCR Complexes with Smart Drug-like Peptides
Abstract G protein-coupled receptors (GPCRs) are a superfamily of proteins classically described as monomeric transmembrane (TM) receptors. However, increasing evidence…
transmembrane peptides
Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
Abstract Membrane proteins can associate into larger complexes. Examples include receptor tyrosine complexes, ion channels, transporters, and G protein–coupled receptors…