Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action
Abstract Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils…
transient receptor potential channels
Mechanisms of Cell Death Induced by Cannabidiol Against Tumor Cells: A Review of Preclinical Studies
Abstract Commonly known as marijuana or hemp, Cannabis sativa L. (Cannabaceae), contains numerous active compounds, particularly cannabinoids, which have been…
A systematic study of molecular targets of cannabidiol in Alzheimer’s disease
Abstract Background: Alzheimer’s disease (AD) is a prevalent, incurable, and chronic neurodegenerative condition characterized by the accumulation of amyloid-β protein…
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological…
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Abstract TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with…
Regulation of transient receptor potential channels by traditional Chinese medicines and their active ingredients
Abstract In recent years, activation of thermal transient receptor potential (TRP) ion channels at a range of temperatures has received…
Structural insights into TRPV2 activation by small molecules
Abstract Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising…
Transient Receptor Potential Cation Channels in Cancer Therapy
Abstract In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid),…
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
Abstract Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs),…
Current and emerging “at-site” pain medications: a review
Abstract The myriad pain pathophysiology has intrigued and challenged humanity for centuries. In this regard, the traditional pain therapies such…