Limited high-throughput screening compatibility of the phenuivirus cap-binding domain
Abstract Bunyaviruses constitute a large and diverse group of viruses encompassing many emerging pathogens, such as Rift Valley fever virus…
target identification
An In Silico Study for Expanding the Utility of Cannabidiol in Alzheimer’s Disease Therapeutic Development
Abstract Cannabidiol (CBD), a major non-psychoactive component of the cannabis plant, has shown therapeutic potential in Alzheimer’s disease (AD). In…
CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications
Abstract Target identification is a crucial process in drug development, aiming to identify key proteins, genes, and signal pathways involved…
Hippocampal expression of the cannabinoid receptor type 1 in canine epilepsy
Abstract Canine drug-resistant epilepsy is a prevailing issue in veterinary neurology. Alternative or additional treatment with cannabinoids is showing promising…
Whole proteome mapping of compound-protein interactions
Abstract Off-target binding is one of the primary causes of toxic side effects of drugs in clinical development, resulting in…
Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia
Abstract Anticancer properties of non-psychoactive cannabinoid cannabidiol (CBD) have been demonstrated on tumors of different histogenesis. Different molecular targets for…