The BRCAness Landscape of Cancer
Abstract BRCAness refers to the damaged homologous recombination (HR) function due to the defects in HR-involved non-BRCA1/2 genes. BRCAness is…
Synthetic lethality
Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis
Keywords: ACC, adrenocortical carcinoma, BLCA, bladder urothelial carcinoma, BRCA, breast invasive carcinoma, CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma,…
Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1
Abstract Cohesin is a multi-protein complex that tethers sister chromatids during mitosis and mediates DNA repair, genome compartmentalisation and regulation…
TP53 mutations, expression and interaction networks in human cancers
Abstract Although the associations of p53 dysfunction, p53 interaction networks and oncogenesis have been widely explored, a systematic analysis of…