Prenatal cannabinoid exposure alters excitation-inhibition balance through glutamate and GABA receptor-mediated signaling
Abstract The growing perception that marijuana is safe during pregnancy has led to a marked increase in prenatal cannabis use,…
synaptic plasticity
Role of Concentration in Opposing Effects of Anandamide on Nociceptive Synapses versus Non-nociceptive Synapses
Abstract There is considerable interest in cannabinoid-based therapies to treat pain, but activation of the endogenous cannabinoid (endocannabinoid) system can…
Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Abstract Background and Objective: Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B…
Cannabidiol reverses depression-like behaviors by enhancing hippocampal synaptic plasticity in rats with chronic restraint stress
Abstract Background and Aim: Major depressive disorder is a prevalent psychiatric condition associated with impaired neuroplasticity, particularly in the hippocampus.…
The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity
Abstract Impairment of neuronal plasticity is involved in a spectrum of neurological disorders such as epilepsy, yet its regulatory mechanisms…
Synaptic signatures of perinatal cannabinoids: A systematic review of rodent hippocampal synaptic plasticity, learning, and memory
Abstract The expanding legalization of cannabis raises significant public health concerns about its use during pregnancy, particularly due to the…
Cannabidiolic Acid Rescues Deficits in Hippocampal Long-Term Potentiation in Models of Alzheimer’s Disease: An Electrophysiological and Proteomic Analysis
Abstract In this study, we have examined the neuroprotective effects of cannabidiolic acid (CBDA) in models of Alzheimer’s disease (AD).…
Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
Abstract Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors…
Reelin Deficiency and Synaptic Impairment in the Adolescent Prefrontal Cortex Following Initial Synthetic Cannabinoid Exposure
Abstract Background: Adolescent cannabinoid exposure can have long-lasting effects on the brain, particularly in the prefrontal cortex, where the reelin…
The effect of traumatic brain injury on learning and memory: A synaptic focus
Abstract Deficits in learning and memory are some of the most commonly reported symptoms following a traumatic brain injury (TBI).…