DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein
Abstract Neutrophil extracellular traps (NETs) are produced through ejection of genomic DNA by neutrophils into extracellular space and serve as…
Surface plasmon resonance
Structural analysis of cannabinoids against EGFR-TK leads a novel target against EGFR-driven cell lines
Abstract Epidermal growth factor receptor (EGFR) is a member of the ErbB family of proteins and are involved in downstream…
Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase
Abstract Simple Summary: Kynurenine-3-monooxygenase (KMO) is an enzyme in the neurotoxic branch of the kynurenine pathway (KP) and is a…
Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding Affinity
Abstract The replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its main protease (Mpro), which…
Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail
Abstract Eukaryotic mRNAs possess a poly(A) tail at their 3′-end, to which poly(A)-binding protein C1 (PABPC1) binds and recruits other…
Receptor Binding Affinities of Synthetic Cannabinoids Determined by Non-Isotopic Receptor Binding Assay
Abstract A major predictor of the efficacy of natural or synthetic cannabinoids is their binding affinity to the cannabinoid type…