Structural basis of THC analog activity at the Cannabinoid 1 receptor
Abstract Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions,…
Structural biology
The biosynthesis of the odorant 2-methylisoborneol is compartmentalized inside a protein shell
Abstract Terpenoids are the largest class of natural products, found across all domains of life. One of the most abundant…
Autoregulatory mechanism of enzyme activity by the nuclear localization signal of lysine-specific demethylase 1
Abstract The N-terminal region of the human lysine-specific demethylase 1 (LSD1) has no predicted structural elements, contains a nuclear localization…
Molecular pharmacology of the onco-TRP channel TRPV6
Abstract TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the…
Structural Insights into Mouse H-FABP
Abstract Intracellular fatty acid-binding proteins are evolutionarily highly conserved proteins. The major functions and responsibilities of this family are the…
Crystal structure of higher plant heme oxygenase-1 and its mechanism of interaction with ferredoxin
Abstract Heme oxygenase (HO) converts heme to carbon monoxide, biliverdin, and free iron, products that are essential in cellular redox…
The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Abstract Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly…
Orchestration of signaling by structural disorder in class 1 cytokine receptors
Abstract Background: Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the…
Cannabinoids and Cannabinoid Receptors: The Story so Far
Abstract Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case,…
Engineering protein assemblies with allosteric control via monomer fold-switching
Abstract The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite…