Effects of Phytocannabinoids on Reproductive System and Prenatal Development: Mechanisms and Clinical Implications
Abstract Cannabis is one of the most studied psychoactive substances due to its increasing prevalence and evolving legal status. Of…
spermatogenesis
Circular RNAs: novel noncoding players in male infertility
Abstract Infertility is a global problem being associated with emotional and financial burden. Recent studies have shown contribution of a…
The Acute Exposure of Human Adult Testis Tissue to Cannabinoids THC and CBD Does Not Impact Testosterone Production Nor Germ Cell Lineage
Abstract Purpose: While an increased risk of developing germ cell tumors has been established in regular cannabis consumers, there is…
Phytocannabinoids, the Endocannabinoid System and Male Reproduction
Abstract The endocannabinoid system (ECS) is comprised of a set of lipid-derived messengers (the endocannabinoids, ECBs), proteins that control their…
Evaluation of the impact of marijuana use on semen quality: a prospective analysis
Abstract Aims: To assess if marijuana consumption – prevalent among men of reproductive age and becoming widespread due to decriminalization…
Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells
Abstract The objective of this work has been to characterize the estrogenic activity of bisphenol-A (BPA) and the adverse effects…
Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin
Abstract Men consume the most nicotine and cannabis products but impacts on sperm epigenetics are poorly characterized. Evidence suggests that…
Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells
Abstract Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and…
Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level
Abstract Endocannabinoids (eCBs) are natural lipids regulating a large array of physiological functions and behaviors in vertebrates. The eCB system…
The Endocannabinoid System and Spermatogenesis
Abstract Spermatogenesis is a complex process in which male germ cells undergo a mitotic phase followed by meiosis and by…