Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability
Abstract Telomerase activity plays an essential role in tumor growth and varies across cancers, typically classified as low or high…
spatial transcriptomics
Glucokinase Regulatory Protein (GCKR) Links Metabolic Reprogramming With Immune Exclusion: Insights From a Pan-Cancer Analysis and Gastric Cancer Validation
Abstract Glucokinase regulatory protein (GCKR) is a metabolic regulator implicated in glucose homeostasis, but its genetic and functional roles in…
A spatially resolved transcriptome landscape during thyroid cancer progression
Abstract Tumor microenvironment (TME) remodeling plays a pivotal role in thyroid cancer progression, yet its spatial dynamics remain unclear. In…
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Abstract To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with…