The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers
Abstract Simple Summary: The human UDP-glycosyltransferase (UGT) superfamily is involved in the metabolism of numerous anticancer drugs and endobiotic signaling…
somatic mutation
Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes
Abstract Mutational processes in tumors create distinctive patterns of mutations, composed of neutral “passenger” mutations and oncogenic drivers that have…
Comprehensive Analysis of Large-Scale Transcriptomes from Multiple Cancer Types
Abstract Various abnormalities of transcriptional regulation revealed by RNA sequencing (RNA-seq) have been reported in cancers. However, strategies to integrate…
EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling
Abstract Background: Somatic mutations are involved in hepatocellular carcinoma (HCC) progression, but the genetic mechanism associated to hepatocarcinogenesis remains poorly…
TOOme: A Novel Computational Framework to Infer Cancer Tissue-of-Origin by Integrating Both Gene Mutation and Expression
Abstract Metastatic cancers require further diagnosis to determine their primary tumor sites. However, the tissue-of-origin for around 5% tumors could…
A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes
Abstract Background: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies…
Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains
Abstract Background: Discriminating driver mutations from the ones that play no role in cancer is a severe bottleneck in elucidating…