Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Abstract Persistent sodium current (INaP) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of…
Sodium channel blocker
Cannabidiol Increases Seizure Resistance and Improves Behavior in an Scn8a Mouse Model
Abstract Voltage-gated sodium channel genes are an important family of human epilepsy genes. De novo missense mutations in SCN8A (encoding…
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Abstract Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and…