Modulatory Effects of “Minor” Cannabinoids in an in vitro Model of Neuronal Hypersensitivity
Abstract Aim: Effective treatment for neuropathic pain remains an unmet clinical need. The therapeutic benefits of the Cannabis plant are…
sensory neurons
Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
Abstract Chronic pain is a major health problem worldwide; however, treatment options remain limited and often involve adverse side-effects or…
Terpenes in Cannabis sativa Inhibit Capsaicin Responses in Rat DRG Neurons via Na+/K+ ATPase Activation
Abstract Terpenes in Cannabis sativa exert analgesic effects, but the mechanisms are uncertain. We examined the effects of 10 terpenes…
Voltage-gated sodium channels in diabetic sensory neuropathy: Function, modulation, and therapeutic potential
Abstract Voltage-gated sodium channels (NaV) are the main contributors to action potential generation and essential players in establishing neuronal excitability.…