Peroxisomal Alterations in Prostate Cancer: Metabolic Shifts and Clinical Relevance
Abstract Peroxisomes have attracted growing interest for their potential role in prostate cancer, a disease characterized by metabolic features distinct…
Selective androgen receptor modulator
Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies
Abstract Background: Breast cancer therapy has been facing remarkable changes. Classic treatments are now combined with other therapies to improve…
Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages
Abstract There is now increasing recognition of the important role of androgen receptor (AR) in modulating immune function. To gain…
Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive Breast Tumors: Unveiling Its Benefits with Aromatase Inhibitors
Abstract Simple Summary: Estrogen receptor-positive (ER+) breast cancer is the most prevalent breast cancer subtype, accounting for 70–85% of all…
Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer
Abstract Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic…
Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)
Abstract Muscle wasting in cancer is a common and often occult condition that can occur prior to overt signs of…