Single‐Cell and Multiomics Characterization of p21 in Cancer Progression and Therapeutic Sensitivity
Abstract Introduction: CDKN1A (encoding p21) is a canonical regulator of cell cycle arrest and genomic stability. However, its functional spectrum…
scRNA-seq
Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region
Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from…
Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region
Abstract The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and…
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer
Abstract Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy. Cannabidiol (CBD) is a non-psychoactive…