Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function
Abstract The genome is pervasively transcribed across various species, yielding numerous non-coding RNAs. As a counterbalance for pervasive transcription, various…
RNA exosome
The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts
Abstract Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Many transcripts are short lived due to their nuclear…
Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions
Abstract Nuclear RNA metabolism is influenced by protein complexes connecting to both RNA-productive and -destructive pathways. The ZC3H18 protein binds…