Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1
Abstract The cannabinoid receptor 1 (CB1) is famous as the target of Δ9-tetrahydrocannabinol (THC), which is the active ingredient of…
rimonabant
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene…
Rimonabant and Cannabidiol Rewrite the Interactions between Breast Cancer Cells and Tumor Microenvironment
Abstract The spread of breast cancer to distant sites is the major cause of death in breast cancer patients. Increasing…
Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge
Abstract Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders…
High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain
Abstract Background: The insulin-sensitizing phytocannabinoid, Δ(9)-tetrahydrocannabivarin (THCV) can signal partly via G-protein coupled receptor-55 (GPR55 behaving as either an agonist…
Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity
Abstract The endocannabinoid system represents an integrated neuronal network involved in the control of several organisms’ functions, such as feeding…
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors
Abstract Cannabinoid (CB) and opioid systems are both involved in analgesia, food intake, mood and behavior. Due to the co-localization…
A Cannabinoid Receptor Agonist N-Arachidonoyl Dopamine Inhibits Adipocyte Differentiation in Human Mesenchymal Stem Cells
Abstract Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member…
Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies
Abstract The central nervous system plays an important role in regulating bone metabolism in health and in disease with a…