Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1
Abstract The cannabinoid receptor 1 (CB1) is famous as the target of Δ9-tetrahydrocannabinol (THC), which is the active ingredient of…
Abstract The cannabinoid receptor 1 (CB1) is famous as the target of Δ9-tetrahydrocannabinol (THC), which is the active ingredient of…
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene…
Abstract The spread of breast cancer to distant sites is the major cause of death in breast cancer patients. Increasing…
Abstract Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders…
Abstract Background: The insulin-sensitizing phytocannabinoid, Δ(9)-tetrahydrocannabivarin (THCV) can signal partly via G-protein coupled receptor-55 (GPR55 behaving as either an agonist…
Abstract The endocannabinoid system represents an integrated neuronal network involved in the control of several organisms’ functions, such as feeding…
Abstract Cannabinoid (CB) and opioid systems are both involved in analgesia, food intake, mood and behavior. Due to the co-localization…
Abstract Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member…
Abstract The central nervous system plays an important role in regulating bone metabolism in health and in disease with a…