HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation
Abstract Background: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer and has shown a rising incidence…
protein-protein interaction
The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A
Abstract Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor…
Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets
Abstract Crotoxin, from the venom of the South American rattlesnake Crotalus durissus terrificus, is a potent heterodimeric presynaptic β-neurotoxin that…
PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer
Keywords: Cancer, Microsatellite instability, Gene expression profiling, Machine learning, Algorithm, Classification, AUC, area under the curve, CV, cross validation, GEO,…
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies
Abstract We recently identified Secernin-1 (SCRN1) as a novel amyloid plaque associated protein using localized proteomics. Immunohistochemistry studies confirmed that…
Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
Abstract Membrane proteins can associate into larger complexes. Examples include receptor tyrosine complexes, ion channels, transporters, and G protein–coupled receptors…
A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors
Abstract Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine…
A molecular mechanism of chaperone-client recognition
Abstract Conformation and dynamics of a chaperone-client interaction at the atomic level show a basic underlying mechanism. Article type: Research…
The juxtamembrane domain of the E-cadherin cytoplasmic tail contributes to its interaction with Myosin VI
Abstract We recently identified the atypical myosin, Myosin VI, as a component of epithelial cell-cell junctions that interacts with E-cadherin.…