“In the light of evolution:” keratins as exceptional tumor biomarkers
Abstract Keratins (KRTs) are the intermediate filament-forming proteins of epithelial cells, classified, according to their physicochemical properties, into “soft” and…
protein interaction network
Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms
Abstract WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ signalling pathway by alternate isoform…
INBIA: a boosting methodology for proteomic network inference
Abstract Background: The analysis of tissue-specific protein interaction networks and their functional enrichment in pathological and normal tissues provides insights…
Integrating omics data and protein interaction networks to prioritize driver genes in cancer
Abstract Although numerous approaches have been proposed to discern driver from passenger, identification of driver genes remains a critical challenge…
LNDriver: identifying driver genes by integrating mutation and expression data based on gene-gene interaction network
Abstract Background: Cancer is a complex disease which is characterized by the accumulation of genetic alterations during the patient’s lifetime.…