FibrilPaint to determine the length of Tau amyloids in fluids
Abstract The Tau protein forms amyloid fibrils in diseases like Alzheimer’s. Development of Tau fibrils correlate with disease progression. Until…
protein aggregation
Targeting Protein Misfolding and Aggregation as a Therapeutic Perspective in Neurodegenerative Disorders
Abstract The abnormal deposition and intercellular propagation of disease-specific protein play a central role in the pathogenesis of many neurodegenerative…
Alzheimer’s Disease: Exploring the Landscape of Cognitive Decline
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The…
The Potential of Metabolomics to Find Proper Biomarkers for Addressing the Neuroprotective Efficacy of Drugs Aimed at Delaying Parkinson’s and Alzheimer’s Disease Progression
Abstract The first objective is to highlight the lack of tools to measure whether a given intervention affords neuroprotection in…
Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions
Abstract Abnormal trinucleotide repeat expansions alter protein conformation causing malfunction and contribute to a significant number of incurable human diseases.…
Rational optimization of a transcription factor activation domain inhibitor
Abstract Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable’ in part due to the…
Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity
Abstract Abnormal polyglutamine (polyQ) expansion and fibrillization occur in Huntington’s disease (HD). Amyloid modifier SERF enhances amyloid formation, but the…
Hsp40s play complementary roles in the prevention of tau amyloid formation
Abstract The microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as Alzheimer’s disease.…
Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies
Abstract The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer’s disease (AD), we previously…