Peroxisomal Alterations in Prostate Cancer: Metabolic Shifts and Clinical Relevance
Abstract Peroxisomes have attracted growing interest for their potential role in prostate cancer, a disease characterized by metabolic features distinct…
prostate cancer
Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination
Abstract While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send…
Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy
Abstract Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate…
Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
Keywords: TME, tumor microenvironment, CAF, cancer-associated fibroblasts, EMT, epithelial-mesenchymal transition, DLBC, diffuse large B-cell lymphoma, TCGA, The Cancer Genome Atlas,…
Nuclear Receptor Coregulators in Hormone-Dependent Cancers
Abstract Simple Summary: Altered nuclear receptor signaling is well-established to contribute to a range of hormone-dependent cancers and therefore they…
The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
Abstract Simple Summary: Prostate cancer, after lung cancer, is the leading cause of death among men. The incidence rate of…
Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies
Abstract Prostate cancer is a major cause of death among men worldwide. Recent preclinical evidence implicates cannabinoids as powerful regulators…
Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer
Abstract Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and…
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
Abstract Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs),…