Abstract Background: Atypical parkinsonian syndromes are rare, fatal neurodegenerative diseases associated with abnormal protein accumulation in the brain. Examples of…
Abstract Purpose: Ocular motor abnormalities such as abnormal saccades are common in idiopathic Parkinson’s disease (PD) and atypical parkinsonian syndrome,…
Abstract Aims: This study aimed to clarify the different topographical distribution of tau pathology between progressive supranuclear palsy (PSP) and…
Abstract Primary 4‐repeat tauopathies with frontotemporal lobar degeneration (FTLD) like Progressive Supranuclear Palsy (PSP) or Corticobasal Degeneration (CBD) show diverse…
Abstract Electronic supplementary material: The online version of this article (10.1186/s40478-020-01035-z) contains supplementary material, which is available to authorized users.…
Abstract Corticobasal degeneration typically progresses gradually over 5–7 years from onset till death. Fulminant corticobasal degeneration cases with a rapidly…
Abstract The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer’s disease (AD), we previously…
Abstract Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by…
Abstract Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well as…
Abstract Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are the most common atypical parkinsonisms. These…