Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis
Abstract Monoamine oxidase B (MAOB) is an enzyme implicated in various physiological and pathological processes, particularly in the context of…
Prognostic markers
BRPF1 in cancer epigenetics: a key regulator of histone acetylation and a promising therapeutic target
Abstract Bromodomain and PHD finger-containing protein 1 (BRPF1) is an essential component of histone acetyltransferase complexes, where it acts as…
Integrative analysis identifies TEAD4 as a universal prognostic biomarker in human cancers
Abstract Introduction: TEA domain transcription factor 4 (TEAD4), a key effector of the Hippo signaling pathway, has been increasingly associated…
JCHAIN: A Prognostic Marker Based on Pan-Cancer Analysis to Inhibit Breast Cancer Progression
Abstract Background/Objectives: The JCHAIN (immunoglobulin-linked chain) is a multimeric IgA and IgM-linked chain whose involvement in oncogenesis and immunomodulation is…
RXRG as a Novel Biomarker and its Correlation With Immune Infiltration in Thyroid Carcinoma
Abstract Background/Aim: Thyroid carcinoma (THCA) is the most prevalent type of endocrine cancer. Retinoid X Receptor Gamma (RXRG) encodes a…
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Abstract Loss of the Y chromosome (LOY) in peripheral blood mononuclear cells (PBMCs) is the most common somatic alteration in…
APOA1 promotes tumor proliferation and migration and may be a potential pan-cancer biomarker and immunotherapy target
Abstract APOA1 was aberrantly expressed in a multitude of tumor types and exhibited variability across various tumor stages. Overexpression of…
Pan-Cancer Characterization Identifies SLC19A1 as an Unfavorable Prognostic Marker and Associates It with Tumor Infiltration Features
Abstract Background: Recent studies have identified solute carrier family 19 member 1 (SLC19A1) as a second messenger transporter that regulates…
Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis
Abstract Purpose: Interleukin-6 (IL-6) is a central factor linking inflammation to cancer. This study aimed to provide a comprehensive assessment…
Comprehensive analysis of PDE2A: a novel biomarker for prognostic value and immunotherapeutic potential in human cancers
Abstract Phosphodiesterase 2A (PDE2A) plays a pivotal role in modulating cyclic nucleotide metabolism. Recent studies have shown that PDE2A is…