Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
Abstract Aim: Insulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family.…
prognostic biomarker
PPM1D is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma
Abstract Background: Protein phosphatase magnesium-dependent 1 delta (PPM1D), also referred to as wild-type p53-induced phosphatase 1 (Wip1) or protein phosphatase…
Prognostic and immunological role of Ras-related protein Rap1b in pan-cancer
Abstract Ras-related Protein Rap1b, a GTP-binding protein belonging to the proximal RAS, which affects tumor progression through regulating tumor cell…
Identification of Claudin-6 as a Molecular Biomarker in Pan-Cancer Through Multiple Omics Integrative Analysis
Abstract Claudin-6 (CLDN6) is one of the 27 family members of claudins and majorly involved in the tight junction and…
Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer
Abstract Recent publications have presented research showing that WD repeat domain 4 (WDR4) plays a significant role in various kinds…
The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
Abstract There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in…
Analysis of the Prognostic Value and Potential Molecular Mechanisms of TREM-1 Overexpression in Papillary Thyroid Cancer via Bioinformatics Methods
Abstract Background: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been reported as a biomarker in many cancers. However, the…
An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity
Abstract Studies have shown that transcription factor activating enhancer binding protein 4 (TFAP4) plays a vital role in multiple types…
Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods
Abstract Background: Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of…
Bioinformatics analysis of the clinical value and potential mechanisms of AHNAK2 in papillary thyroid carcinoma
Abstract Background: AHNAK2 has been recently reported as a biomarker in many cancers. However, a systematic investigation of AHNAK2 in…