Single‐Cell and Multiomics Characterization of p21 in Cancer Progression and Therapeutic Sensitivity
Abstract Introduction: CDKN1A (encoding p21) is a canonical regulator of cell cycle arrest and genomic stability. However, its functional spectrum…
prognostic biomarker
Integrated pan-cancer multi-omics profiling and experimental validation identify LSM12 as a prognostic biomarker and candidate therapeutic target in human cancers
Abstract Background: RNA metabolism regulators remain insufficiently characterized across tumor types, despite the substantial expansion of multi-omics datasets. LSM12, a…
A Comprehensive Pan-Cancer Analysis Revealing IGF2 Gene as a Diagnostic and Prognostic Biomarker
Abstract Background: Cancer, one of the leading causes of mortality worldwide, is driven by genetic alterations promoting uncontrolled cell growth…
ATOH1 and NPAS1 are immune related prognostic biomarkers in colorectal cancer
Abstract Background: Basic helix-loop-helix (bHLH) transcription factors are implicated in tumorigenesis, but their comprehensive role in colorectal cancer (CRC) remains…
Comprehensive Pan-Cancer Analysis Identifies POFUT1 as a Prognostic Biomarker and Potential Therapeutic Target Associated with Immune Evasions
Abstract Cancer remains a leading cause of death worldwide, and identifying new molecular targets for diagnosis and treatment is critical.…
DHRS7 is an immune-related prognostic biomarker of KIRC and pan-cancer
Abstract Renal clear cell carcinoma (KIRC) is one malignancy whose development and prognosis have been associated with aberrant DHRS7 expression.…