Abstract The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of…
Abstract Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753). This naturally occurring secondary metabolite does not…
Abstract Endocannabinoids (eCBS) are endogenously derived lipid signaling molecules that serve as tissue hormones and interact with multiple targets, mostly…
Abstract Off-target binding is one of the primary causes of toxic side effects of drugs in clinical development, resulting in…
Abstract Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools…
Abstract Molecular docking is an established in silico structure-based method widely used in drug discovery. Docking enables the identification of…
Abstract Background: Several web-based tools have been reported recently which predict the possible targets of a small molecule by similarity…
Abstract Background and purpose: 4′-O-methylhonokiol (MH) is a natural product showing anti-inflammatory, anti-osteoclastogenic, and neuroprotective effects. MH was reported to…
Abstract Drug abuse (DA) and addiction is a complex illness, broadly viewed as a neurobiological impairment with genetic and environmental…